Centres Rory Hutchinson and Matt Proctor coming into the starting line-up, while full-back George Furbank and scrum-half Alex Mitchell are the only two Saints to remain in the back line from last weekend. Tom Collins and Ryan Olowofela line up on the wings, with Reuben Bird-Tulloch and Tui Uru set for their first league appearances for Northampton from the bench, with new signing Tom James primed for his club debut if he enters the action. London Irish: 15.

Tom Homer, 14. Ben Loader, 13. Matt Williams, 12. Theo Brophy Clews, 11. Ollie Hassell-Collins, 10. Paddy Jackson, 9. Ben Meehan, 1. Allan Dell, 2. Matt Cornish, 3. Ollie Hoskins, 4. George Nott, 5. Sebastian de Chaves, 6. Jack Cooke, 7. Blair Cowan (capt), 8. Albert Tuisue. Replacements: 16. Motu Matu’u, 17. Will Goodrick-Clarke, 18.

Blair Cowan starts at openside flanker and captains the side, and Albert Tuisue keeps the No. 8 jersey. Ben Meehan partners Paddy Jackson in the halfbacks and Theo Brophy Clews and Matt Williams form the centre partnership. Ollie Hassell-Collins and Ben Loader are named on the wings, with Tom Homer at full-back in his first appearance since re-joining the club.

Live Rugby: London Irish Vs Saints - Channel 5